As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

A postdoctoral research position is available from March 2019 in the Schiller lab (Institute of Lung Biology and Disease) at Helmholtz Zentrum München. The full-time position is fully funded for a duration of two years with the possibility of extension. Transnational mobility and application for a postdoctoral fellowship (Marie Curie, Embo, etc) is most welcome.

We are looking for highly motivated individuals ideally with a strong background in biology. Previous experience with systems biology approaches is expected. Experience with lung biology and disease and animal models thereof is a big advantage. Possible projects include establishment of single cell and nuclei multi-omics analysis of mouse models of disease and human lungs and functional analysis of newly discovered cell states in mouse lung (mouse genetics, lineage tracing, imaging). The data analysis part will include application of state of the art analytical tools for scRNAseq data in close collaboration with the Institute of Computational Biology at HMGU (Theis lab).

The Schiller lab is using systems biology tools, such as mass spectrometry driven proteomics and single cell transcriptomics, in combination with mouse models of lung disease and human patient samples, to identify fundamental molecular principles of lung regeneration and fibrosis. Dr. Schiller has a longstanding interest in cell adhesion and extracellular matrix (ECM) biology and developed state of the art mass spectrometry methodology for in depth characterization of cell-matrix adhesions and ECM in health and disease. Combining proteomics and single cell transcriptomics, the Schiller lab (in collaboration with the Theis lab) recently charted the molecular and cellular changes in the aging mouse lung at single cell resolution, discovering aging hallmarks and predicting the cellular sources of regulated proteins (Angelidis et al, Nature Communications 2019).

At the next possible time the ILBD is looking for a

Postdoc for Research project "Experimental Systems Biology of Lung Regeneration and Fibrosis" (f/m/d) 2018/0566